Synthesis, Characterization, and SERS Functionalization of Hollow Gold Nanoparticles
نویسندگان
چکیده
Hollow gold nanoparticles formed by galvanic replacement reactions have been extensively studied because their increased surface area and tunable optical properties have applications in catalysis, drug delivery, and photothermal cancer therapies. In this study, hollow gold nanoparticles (size 30-40 nm) were synthesized by transmetallation of tyrosinereduced sacrificial solid silver nanospheres. UV-vis-NIR spectroscopy and TEM imaging of the samples taken during the reaction showed the formation of hollow, porous gold nanospheres. The nanoparticles were then successfully functionalized with PEG-thiol and 5-mercaptopentanenitrile (a Raman dye), and SERS imaging of live cells was attempted but not achieved. Dye-functionalized nanoparticles reduced MTT and interfered with cytotoxicity assay results.
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